Location, Location, Location: The Impact of Migratory Heterogeneity on T Cell Function

Location, Location, Location: The Impact of Migratory Heterogeneity on T Cell Function

T cell migration is crucial for an effective adaptive immune response to invading pathogens. Naive and memory T cells encounter pathogen antigens, become activated, and differentiate into effector cells in secondary lymphoid tissues, and then migrate to the site(s) of infection where they exert effector activities that control and eliminate pathogens. To achieve activation, efficient effector f...

Location, Location, Location and Location Facility Location Incorporating Demand Uncertainty, Logistic Network Design, Product Heterogeneity and Competition Location, Location, Location and Location Facility Location Incorporating Demand Uncertainty, Logistic Network De- Sign, Product Heterogeneity and Competition

Choosing locations to provide service under various constraints and objectives is an essential logistic activity in several contexts. Manufacturers choose locations for facilities and sales depots, government agencies choose locations for fire stations and other service installations, politicians choose ideological positions in the space of political agendas, etc. The field of location theory i...

Location, Location, Location: The Impact of Guideline Grid Location on the Value of Sentencing Enhancements Given By Judges in Maryland

Location, location, location...

Intra-abdominal fat is an established risk factor for the metabolic syndrome. In this issue of Cell Metabolism, Tran et al. (2008) test the cell-autonomous and location-related properties of transplanted intra-abdominal and subcutaneous fat depots. While subcutaneous fat seems to confer metabolic benefits, species differences in adipose biology justify caution in interpreting the results.

The business of deubiquitination - location, location, location.

A majority of proteins in the cell can be modified by ubiquitination, thereby altering their function or stability. This ubiquitination is controlled by both ubiquitinating and deubiquitinating enzymes (DUBs). The number of ubiquitin ligases exceeds that of DUBs by about eightfold, indicating that DUBs may have much broader substrate specificity. Despite this, DUBs have been shown to have quite...